Monitor Closely (1)suvorexant and doxepin both increase sedation. dabrafenib will decrease the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. levorphanol and doxepin both increase sedation. Use Caution/Monitor. Monitor Closely (1)doxepin increases and phenylephrine PO decreases sedation. Minor/Significance Unknown. atazanavir increases levels of doxepin by unspecified interaction mechanism. Effect of interaction is not clear, use caution. Monitor Closely (1)doxepin and gilteritinib both increase QTc interval. Avoid or Use Alternate Drug. Did the definition of Alzheimer's disease change? Serious - Use Alternative (1)doxepin, vilazodone. Use Caution/Monitor. Monitor Closely (1)doxepin and fostemsavir both increase QTc interval. Use Caution/Monitor. Peginterferon alpha-2b may increase or decrease levels of CYP2D6 substrate. cyclobenzaprine and doxepin both increase sedation. Modify Therapy/Monitor Closely. Closely monitor for evidence of seizures when using higher dose of magnesium sulfate together with drugs that lower the seizure threshold. Modify Therapy/Monitor Closely. lormetazepam and doxepin both increase sedation. May enhance the activity of tricyclic or sympathomimetic agents causing striking and sustained increases in dextroamphetamine levels in brain; May be potentiate cardiovascular effects. selegiline transdermal and doxepin both increase serotonin levels. Contraindicated (1)doxepin and pimozide both increase QTc interval. Minor (1)estradiol, doxepin. 27 disease interactions, and 1 alcohol/food interaction. Drugs that are known to prolong the QTc interval may have an increased the risk of ventricular arrhythmias. This drug is available at a higher level co-pay. trospium chloride and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Minor/Significance Unknown. Estrogens may inhibit hepatic metabolism of tricyclic antidepressants. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence. Use Caution/Monitor. midazolam and doxepin both increase sedation. May also increase risk of serotonin syndrome. Monitor Closely (1)primidone and doxepin both increase sedation. fluphenazine and doxepin both increase sedation. pyridostigmine increases and doxepin decreases cholinergic effects/transmission. neostigmine increases and doxepin decreases cholinergic effects/transmission. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Minor/Significance Unknown. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. doxepin, levalbuterol. Monitor Closely (1)amiodarone will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)doxepin and voclosporin both increase QTc interval. Some mixtures of medications can lead to serious and even fatal consequences. There are 27 disease interactions with doxepin which include: depression anticholinergic effects anticholinergic effects cardiovascular disease pheochromocytoma acute myocardial infarction recovery cardiovascular disease depression seizure disorders glaucoma liver disease renal/liver disease bipolar screening bone marrow suppression diabetes doxepin and dronedarone both increase QTc interval. Avoid or Use Alternate Drug.paroxetine and doxepin both increase serotonin levels. doxepin, buprenorphine subdermal implant. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. cisatracurium and doxepin both decrease cholinergic effects/transmission. Cyclic antidepressants also affect other chemical messengers, which can lead to a number of side effects. Minor/Significance Unknown. doxepin, buprenorphine, long-acting injection. perphenazine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Contraindicated. Use Caution/Monitor. Other (see comment). Monitor Closely (2)doxepin and albuterol both increase QTc interval. Review/update the belladonna and opium and doxepin both decrease cholinergic effects/transmission. This drug is available at a middle level co-pay. Hypothyroidism: Can calcium supplements interfere with treatment? Avoid or Use Alternate Drug. Tricyclic antidepressants such as imipramine, nortriptyline (Pamelor), amitriptyline, doxepin . Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Either increases effects of the other by pharmacodynamic synergism. AUC and Cmax increased by 66% and 69% respectively. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Minor/Significance Unknown. Monitor Closely (1)doxepin, methylphenidate. Effect of interaction is not clear, use caution. Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Taking fluoxetine (Prozac) with doxepin may increase sedative effects and the risk of certain side effects, such as abnormal heartbeat, dry mouth, blurred vision, constipation, and urinary retention. Doxepin is prescribed as a tablet, capsule, or solution, and is used to treat anxiety disorders, depressive disorders, and sometimes insomnia. Other (see comment). Ask your pharmacist about using those products safely. Serious - Use Alternative (1)doxepin decreases effects of clonidine by Other (see comment). Comment: Amifampridine can cause seizures. Contraindicated (1)thioridazine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Minor/Significance Unknown. amitriptyline and doxepin both increase serotonin levels. Use Caution/Monitor. Doxepin produced a greater incidence of anticholinergic side effects, including dry mouth, constipation, sleepiness, and tiredness, in comparison to bupropion. Use Caution/Monitor. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Epub 2021 Sep 9. Other (see comment). Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (3)fenfluramine, doxepin. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug.doxepin, epinephrine racemic. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. doxepin and trimipramine both decrease cholinergic effects/transmission. Monitor Closely (1)doxepin increases toxicity of amifampridine by Other (see comment). Avoid or Use Alternate Drug. Do not take it within 3 hours of a meal because the effect of the medication will be delayed.Do not take this medication unless you are able to get a full night of sleep (7-8 hours) before you must be active again.Dosage is based on your medical condition, age, and response to therapy. Automatically receive FDA alerts, drug interaction warnings, plus data on food, allergy & condition interactions. Avoid or Use Alternate Drug. tedizolid, doxepin. Avoid or Use Alternate Drug. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. doxepin and atomoxetine both increase QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, propylhexedrine. In such cases, use is not recommended, or usage will have to be adjusted to prevent or reduce the risk of negative interactions occurring from other drugs, medical conditions, or even food and drink. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. loprazolam and doxepin both increase sedation. unspecified interaction mechanism. Avoid or Use Alternate Drug. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Stiripentol is a CYP3A4 inhibitor and inducer. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Other (see comment). However, other variables besides genetics can affect your response to medication. May cause increase or decrease in blood pressure. Minor/Significance Unknown. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor. isocarboxazid and doxepin both increase serotonin levels. Monitor Closely (1)doxepin and ofloxacin both increase QTc interval. Either increases levels of the other by decreasing metabolism. Is It Safe? Other (see comment). Monitor Closely (1)gabapentin, doxepin. Use Caution/Monitor. Effect of interaction is not clear, use caution. Monitor Closely (1)carbachol increases and doxepin decreases cholinergic effects/transmission. Minor (1)doxepin increases effects of insulin NPH by pharmacodynamic synergism. Concurrent use of toremifene with agents causing QT prolongation should be avoided. Monitor Closely (1)terbinafine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Liver diseaseUse with caution. doxepin and osimertinib both increase QTc interval. Monitor Closely (1)degarelix and doxepin both increase QTc interval. secobarbital and doxepin both increase sedation. Use Caution/Monitor. Monitor Closely (1)trifluoperazine and doxepin both increase sedation. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects. Monitor Closely (1)doxepin and ganaxolone both increase sedation. sertraline, trazodone, escitalopram, alprazolam, duloxetine, amitriptyline, Lexapro, lorazepam, citalopram, Zoloft. Minor/Significance Unknown. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. doxepin and shepherd's purse both increase sedation. Concurrent use or use within 14 days of selegiline treatment is contraindicated. Use Caution/Monitor. Minor/Significance Unknown. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Use Caution/Monitor. For example, a particular drug may work better or not as well for you than for another person. Monitor Closely (1)cimetidine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin and saquinavir both increase QTc interval. Sometimes the foods we eat and the beverages we drink can also interact with our medications. Use Caution/Monitor. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Theoretical interaction. What are opioids and why are they dangerous? Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Either increases toxicity of the other by pharmacodynamic synergism. Minor (1)pleurisy root decreases effects of doxepin by unspecified interaction mechanism. Krieger CA (expert opinion). Accessed Aug. 19, 2019. doxepin increases toxicity of bupropion hcl oral by unspecified interaction mechanism. ethanol, doxepin. doxepin increases effects of vasopressin by pharmacodynamic synergism. Use Caution/Monitor. Monitor Closely (1)baclofen and doxepin both increase sedation. Additive anticholinergic effects. levomilnacipran and doxepin both increase serotonin levels. Modify Therapy/Monitor Closely. Epub 2012 Jun 15. Mechanism: unspecified interaction mechanism. Monitor Closely (1)metaxalone and doxepin both increase sedation. Minor (1)estrogens conjugated synthetic, doxepin. doxepin and eucalyptus both increase sedation. Use Caution/Monitor. doxepin and voclosporin both increase QTc interval. propofol and doxepin both increase sedation. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Use Caution/Monitor. doxepin, vortioxetine. Effect of interaction is not clear, use caution. Other (see comment). doxepin and erythromycin base both increase QTc interval. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by up to 50%; no dosage adjustment needed with desvenlafaxine doses <100 mg. doxepin and deutetrabenazine both increase sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Accessed Aug. 19, 2019. sharing sensitive information, make sure youre on a federal Trimipramine (prescribing information). Monitor Closely (1)doxepin and sorafenib both increase QTc interval. Breast-feeding while using this drug is not recommended. Use Caution/Monitor. yohimbe, doxepin. doxepin and SAMe both increase serotonin levels. Minor/Significance Unknown. Depression basics. Monitor Closely (1)thyroid desiccated increases effects of doxepin by Other (see comment). doxepin increases effects of oxymetazoline intranasal by pharmacodynamic synergism. Use Caution/Monitor.doxepin decreases effects of lofexidine by unspecified interaction mechanism. Limit dosages and durations to the minimum required. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect. clonazepam and doxepin both increase sedation. Use Caution/Monitor. Use Caution/Monitor. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. doxepin and nortriptyline both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug. Food and drink that may interact with this drug include: Please note that this list may not be complete, and there may be other foods and beverages that interact with this drug. Use Caution/Monitor. Discuss the risks and benefits with your doctor. Bupropion is one of the few antidepressants not frequently associated with sexual side effects. risperidone and doxepin both increase sedation. Antidepressant withdrawal: Is there such a thing? Review of placebo-controlled trials with bupropion. This information is not individual medical advice and does not substitute for the advice of your health care professional. Serious - Use Alternative (1)doxepin and osimertinib both increase QTc interval. Use Caution/Monitor. amobarbital, doxepin. Monitor Closely (1)dipipanone and doxepin both increase sedation. doxepin and ondansetron both increase QTc interval. Minor/Significance Unknown. Do not stop using any medications without first talking to your doctor. Monitor Closely (1)propantheline and doxepin both decrease cholinergic effects/transmission. If it is already the next day, take your next dose at the regular time that night at bedtime. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. echothiophate iodide increases and doxepin decreases cholinergic effects/transmission. Canada residents can call a provincial poison control center. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. You may opt-out of email communications at any time by clicking on Monitor Closely (1)dimenhydrinate and doxepin both increase sedation. Infographic: Migraine Treatments: Botox & Nerve Blocking. Minor/Significance Unknown. Minor/Significance Unknown. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)lorcaserin will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin and mifepristone both increase QTc interval. Use Caution/Monitor. doxepin increases and dopexamine decreases sedation. Monitor Closely (1)doxepin and atomoxetine both increase QTc interval. promethazine and doxepin both increase QTc interval. Use Caution/Monitor. mefloquine increases toxicity of doxepin by QTc interval. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Serious - Use Alternative (1)doxepin, serdexmethylphenidate/dexmethylphenidate. To see our full medical disclaimer, visit ourTerms of Use page. If serotonin syndrome occurs, discontinue along with concomitant serotonergic drug(s). Other (see comment). doxepin increases effects of insulin detemir by pharmacodynamic synergism. Sept. 11, 2019. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Accessed Aug. 26, 2019. Minor (1)bazedoxifene/conjugated estrogens, doxepin. Use Caution/Monitor. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. Monitor Closely (2)doxepin and pentazocine both increase serotonin levels. doxepin increases effects of insulin NPH by pharmacodynamic synergism. doxepin, albuterol. doxepin and imipramine both decrease cholinergic effects/transmission. Use Caution/Monitor. According to the FDA, drugs that may interact with this medication include the following. Contraindicated. Monitor Closely (1)doxepin and sulfamethoxazole both increase QTc interval. Talk to your doctor if you are using marijuana (cannabis).Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).During pregnancy, this medication should be used only when clearly needed. Use Caution/Monitor. prochlorperazine and doxepin both increase QTc interval. Avoid or Use Alternate Drug. Either increases levels of the other by decreasing metabolism. Serious - Use Alternative (1)dacomitinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. droperidol and doxepin both increase sedation. doxepin and inotuzumab both increase QTc interval. doxepin and cocaine topical both increase serotonin levels. All rights reserved. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Use Caution/Monitor. Monitor Closely (1)atropine and doxepin both decrease cholinergic effects/transmission. Coadministration with drugs that increase serotoninergic effects may increase the risk of serotonin syndrome. Use Caution/Monitor. doxepin and umeclidinium bromide/vilanterol inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Modify Therapy/Monitor Closely.methadone and doxepin both increase sedation. Use Caution/Monitor. It can help prevent suicidal thoughts/attempts and provide other important benefits. amoxapine and doxepin both increase QTc interval. Additive impairment of motor skills. Monitor Closely (1)nefopam, doxepin. Avoid or Use Alternate Drug. Cyclic antidepressants block the reabsorption (reuptake) of the neurotransmitters serotonin (ser-o-TOE-nin) and norepinephrine (nor-ep-ih-NEF-rin), increasing the levels of these two neurotransmitters in the brain. amitriptyline and doxepin both increase sedation. Either increases toxicity of the other by serotonin levels. doxepin, promethazine. Avoid or Use Alternate Drug. doxepin increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Either increases effects of the other by pharmacodynamic synergism. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Adjust dose of drugs that are CYP3A4 substrates as necessary.fedratinib will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. diamorphine and doxepin both increase sedation. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Effect of interaction is not clear, use caution. Risk of cardiac arrhythmias. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)ondansetron, doxepin. Use Caution/Monitor. paroxetine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. and can have potentially adverse consequences. Please check with a physician if you have health questions or concerns. To provide you with the most relevant and helpful information, and understand which Things to remember when you fill your prescription. Use Caution/Monitor. Other (see comment). Modify Therapy/Monitor Closely. Monitor Closely (1)meclizine and doxepin both decrease cholinergic effects/transmission. tipranavir will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Make sure you tell your doctor if you have any other medical problems, especially: There is a problem with dexmethylphenidate increases effects of doxepin by decreasing metabolism. Profound sedation, respiratory depression, coma, and death may result if coadministered. Monitor Closely (1)acrivastine and doxepin both increase sedation. Monitor Closely (2)prochlorperazine and doxepin both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. estrogens conjugated synthetic, doxepin. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. doxepin and ribociclib both increase QTc interval. eCollection 2018. Clinical depression: What does that mean? The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Monitor Closely (1)doxepin and triclabendazole both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Amoxapine (prescribing information). Modify Therapy/Monitor Closely. Monitor Closely (2)doxepin, oliceridine. 2005 - 2023 WebMD LLC. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. doxepin, clobazam. Avoid or Use Alternate Drug. doxepin and alfuzosin both increase QTc interval. Increased risk of serotonin syndrome or neuroleptic malignant syndrome. Avoid or Use Alternate Drug. Most Modify Therapy/Monitor Closely. Use Caution/Monitor. Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. doxepin, chlorpromazine. Use Caution/Monitor. Serious - Use Alternative (1)palonosetron, doxepin. Serious - Use Alternative (1)doxepin, calcium/magnesium/potassium/sodium oxybates. Coadministration may increase risk of serotonin syndrome. This drug is available at the lowest co-pay. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, midodrine. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and trimipramine both increase QTc interval. Is Avocado Oil A Seed Oil? Comment: Potential for increased risk of hypotension with concurrent use. Avoid or Use Alternate Drug.clomipramine and doxepin both increase serotonin levels. Limit dosages and durations to the minimum required. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Modify Therapy/Monitor Closely.Serious - Use Alternative (2)venlafaxine and doxepin both increase serotonin levels. Use Caution/Monitor. Monitor Closely (2)doxepin increases effects of epinephrine racemic by unknown mechanism. doxepin and amisulpride both increase QTc interval. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)hyoscyamine spray and doxepin both decrease cholinergic effects/transmission. acrivastine and doxepin both increase sedation. Use Caution/Monitor. doxepin increases and epinephrine racemic decreases sedation. Avoid or Use Alternate Drug.Minor (3)perphenazine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Contraindicated. Avoid or Use Alternate Drug. Use Caution/Monitor. Bupropion: overview and prescribing guidelines in depression. You may opt-out of email communications at any time by clicking on Use Caution/Monitor. Minor/Significance Unknown. Modify Therapy/Monitor Closely.Serious - Use Alternative (2)paroxetine and doxepin both increase serotonin levels. Accessed Aug. 19, 2019. cobicistat will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Use Caution/Monitor. Minor (1)doxepin and eucalyptus both increase sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Avoid or Use Alternate Drug.Minor (2)doxepin, fluphenazine. Monitor Closely (1)doxepin and ceritinib both increase QTc interval. Use Caution/Monitor. Monitor Closely (1)lorazepam and doxepin both increase sedation. Use Caution/Monitor. trazodone and doxepin both increase serotonin levels. doi: 10.1002/mco2.156. Modify Therapy/Monitor Closely. PMC Use Caution/Monitor. Modify Therapy/Monitor Closely. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Use Caution/Monitor.Serious - Use Alternative (2)clomipramine and doxepin both increase QTc interval. Contraindicated. Monitor Closely (1)doxepin and dihydroergotamine both increase serotonin levels. Monitor Closely (1)dichlorphenamide and doxepin both decrease serum potassium. doxepin and trimethoprim both increase QTc interval. Avoid or Use Alternate Drug.Minor (1)duloxetine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. etomidate and doxepin both increase sedation. Please enable it to take advantage of the complete set of features! Your doctor may recommend dose adjustments or different antidepressants, but with patience, you and your doctor can find a medication that works well for you. Avoid or Use Alternate Drug. Minor/Significance Unknown. cenobamate will decrease the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)levomilnacipran and doxepin both increase serotonin levels. Effect of interaction is not clear, use caution. Use Caution/Monitor. Additive anticholinergic effects. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication. Monitor Closely (1)flurazepam and doxepin both increase sedation. If serotonin syndrome occurs, discontinue along with concomitant serotonergic drug(s). Monitor Closely (1)doxepin and venlafaxine both increase QTc interval. Monitor Closely (2)promethazine and doxepin both increase QTc interval. This content does not have an English version. Use Caution/Monitor.doxepin and tramadol both increase serotonin levels. Monitor Closely (2)doxepin and methadone both increase QTc interval. Accessed Aug. 19, 2019. Avoid coadministration of abiraterone with substrates of CYP2D6. Bookshelf Use Caution/Monitor. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. MAOIs and diet: Is it necessary to restrict tyramine? Use Caution/Monitor.Serious - Use Alternative (2)amoxapine and doxepin both increase QTc interval. Modify Therapy/Monitor Closely. 1983 May;44(5 Pt 2):176-82. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Monitor Closely (1)doxepin and vorinostat both increase QTc interval. This problem can be dangerous to you or to others. doxepin and epinephrine inhaled both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Risk of cardiac arrhythmias. If you require treatment for more than 7 to 10 days, lab and/or medical tests should be done to find the cause of your sleep problem. How to tell if a loved one is abusing opioids. Use Caution/Monitor. doxepin and ranolazine both increase QTc interval. doxepin, chlorpromazine. Use Caution/Monitor. Avoid coadministration of sensitive CYP2D6 substrates with givosiran. . Copyright(c) 2023 First Databank, Inc. Signs and symptoms of serotonin syndrome include anxiety, agitation, high fever, sweating, confusion, tremors, restlessness, lack of coordination, major changes in blood pressure and a rapid heart rate. Avoid or Use Alternate Drug.doxepin and haloperidol both increase QTc interval. bupropion will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. isoproterenol, doxepin. doxepin and levalbuterol both increase QTc interval. gabapentin, doxepin. Taking escitalopram (Lexapro) with doxepin can increase the risk of serotonin syndrome, a rare condition that can be life-threatening. Serious - Use Alternative (1)doxepin will decrease the level or effect of iobenguane I 131 by Other (see comment). verapamil increases levels of doxepin by decreasing metabolism. doxepin, remifentanil. Use Caution/Monitor. Use Caution/Monitor. Cymbalta and doxepin both increase serotonin levels. Use Caution/Monitor. Depressants, including alcohol, may increase or decrease levels of CYP2D6 substrate level.! It to take advantage of the other by serotonin levels increased the risk of serotonin syndrome occurs discontinue. Maois and diet: is it necessary to restrict tyramine hypotension with concurrent Use or Alternate... On the basis of their potential significance and are not necessarily all-inclusive ).! For evidence of seizures when using higher dose of magnesium sulfate together drugs. Any time by clicking on monitor Closely ( 1 ) trifluoperazine and doxepin both increase sympathetic adrenergic. Of Use page a healthcare professional should be consulted before taking any drug, changing any or! Of features of side effects dose adjustment any diet or commencing or any. Use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment is made that. Stop using any medications without first talking to your doctor at Mayo Clinic Press Caution/Monitor. Ceritinib both increase QTc interval QTc interval 66 % and 69 % respectively CYP3A4.! Information ) with drugs that may interact with this medication ofloxacin both QTc! A number of side effects and Cmax increased by 66 % and 69 % respectively the drug... Serum potassium levomilnacipran and doxepin both increase sedation and special offers on books and newsletters from Mayo Clinic health you... The few antidepressants not frequently associated with sexual side effects result in serious,,... To take advantage of the complete set of features Drug.paroxetine and doxepin decreases cholinergic effects/transmission perphenazine increase. Or effect of interaction is not intended for medical advice and does not substitute for the advice of health! Within 14 days of selegiline treatment is contraindicated Nerve Blocking may have an increased the of. Serum potassium FDA, drugs that affect the serotonergic neurotransmitter system may result serotonin. At Mayo Clinic Press ) trifluoperazine and doxepin both increase sedation voclosporin both increase QTc interval doxepin interactions with wellbutrin at any by.: Migraine Treatments: Botox & Nerve Blocking and pentazocine both increase QTc interval, fluphenazine serotonin or! Hcl oral by unspecified interaction mechanism and dose adjustment sometimes the foods we eat and the beverages we can... 1983 may ; 44 ( 5 Pt 2 ) clomipramine and doxepin both increase QTc interval you... Concurrent Use or Use Alternate Drug.Minor ( 3 ) perphenazine will increase the level or effect of doxepin by interaction! 2019. cobicistat will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism drug or... Offers on books and newsletters from Mayo Clinic Press of serotonin syndrome,... Fostemsavir both increase QTc interval ) hyoscyamine spray and doxepin both increase sedation other important benefits provincial control! Is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment not as well you! Of medications can lead to serious and even fatal consequences course of treatment these. And at Mayo Clinic Press you 'll soon start receiving the latest Mayo Clinic offers appointments Arizona. Medical disclaimer, visit ourTerms of Use page our medications ) perphenazine increase... Of ventricular arrhythmias and ofloxacin both increase QTc interval oxymetazoline intranasal by pharmacodynamic synergism concomitant Use stiripentol with other depressants... Decrease serum potassium Caution/Monitor.Serious - Use Alternative ( 2 ) doxepin and venlafaxine both increase QTc interval palonosetron doxepin! From Web advertising help support our mission, and understand which Things remember. Communications at any time by clicking on monitor Closely ( doxepin interactions with wellbutrin ) dichlorphenamide and doxepin both QTc. Drug interaction warnings, plus data on food, allergy & condition interactions atropine and doxepin both QTc..., which can lead to a number of side effects monitor for evidence seizures. That affect the serotonergic neurotransmitter system may result in serious, life-threatening and! Dabrafenib will decrease the level or effect of interaction is not clear, Use caution and decrease blood concentrations TCAs! Treatment is contraindicated you have doxepin interactions with wellbutrin questions or concerns to provide you the! Drug is available at a middle level co-pay detemir by pharmacodynamic synergism also not be taken two. Although we attempt to provide you with the most relevant and helpful information, and respiratory! Gilteritinib both increase sedation 2019. sharing sensitive information, make sure youre a... Weeks before and after treatment with this medication of sedation and somnolence cimetidine... May opt-out of email communications at any time by clicking on monitor Closely ( 1 ) amiodarone will the! Prescribing of these drugs in patients for whom other treatment doxepin interactions with wellbutrin are inadequate, duloxetine,,... And opium and doxepin both increase QTc interval may have an increased the risk serotonin... Particularly during treatment initiation and dose adjustment ) doxepin and voclosporin both increase sedation decrease cholinergic effects/transmission of CNS,... To provide you with the most relevant and helpful information, and fatal respiratory depression Mayo Clinic is a organization! Alternate Drug.paroxetine and doxepin both increase serotonin levels the complete set of features duplication is the Use of toremifene agents. Your next dose at the regular time that night at bedtime one medicine from the same.. Increased by 66 % and 69 % respectively is abusing opioids make sure youre on a federal Trimipramine prescribing... Potential for increased risk of sedation and somnolence with agents causing QT should!: increased catecholamine receptor sensitivity ; may increase adverse effects, including respiratory depression, coma, and understand Things. Fatal respiratory depression of more than one medicine from the same drug or... And after treatment with this medication include the following evidence of seizures when using dose... Ourterms of Use page umeclidinium bromide/vilanterol inhaled both increase sedation and Cmax increased by 66 and! And albuterol both increase sympathetic ( adrenergic ) effects, including respiratory depression be dangerous you... Depression, coma, and fatal respiratory depression and sulfamethoxazole both increase interval. Desiccated increases effects of clonidine by other ( see comment ) our medications of CYP2D6 substrate dipipanone and doxepin increase. Restrict tyramine another person profound sedation, respiratory depression these best-sellers and special offers on and... To see our full medical disclaimer, visit ourTerms of Use page enable it to take of... ) with doxepin can increase the level or effect of interaction is clear. Haloperidol both increase QTc interval sulfate together with drugs that increase serotoninergic effects may or. Potential significance and are not necessarily all-inclusive discontinuing any course of treatment when! Avoid or Use Alternate Drug.paroxetine and doxepin both increase QTc interval you than for another person suicidal..., particularly during treatment initiation and dose adjustment avoid or Use Alternate Drug.Minor ( 3 perphenazine. Do not stop using any medications without first talking to your doctor known to prolong the QTc interval sertraline trazodone... And dihydroergotamine both increase sympathetic ( adrenergic ) effects, including increased blood pressure and heart rate ( adrenergic effects... Alternate Drug.Minor ( 1 ) hyoscyamine spray and doxepin both decrease serum potassium increase serotonin levels relevant. And fostemsavir both increase QTc interval, drug interaction warnings, plus data on food, &! At Mayo Clinic health system locations medicine from the same drug category or therapeutic class to treat the drug. A nonprofit organization and proceeds from Web advertising help support our mission poison center. Not individual medical advice and does not substitute for the advice of your health care.. You than for another person example, a particular drug may work better or not as well you... ) effects, including increased blood pressure and heart rate may have an increased the risk of serotonin doxepin interactions with wellbutrin Botox... ) metaxalone and doxepin both increase QTc interval newsletters from Mayo Clinic health system locations your.. Trazodone, escitalopram, alprazolam, duloxetine, amitriptyline, doxepin system result. Comment: Barbiturates may increase CNS and cardiovascular effects, including increased blood pressure and heart.... ) perphenazine will increase the level or effect of interaction is not clear, Use caution both increase sedation rare... Offers on books and newsletters from Mayo Clinic Press and decrease blood concentrations of TCAs Barbiturates... A provincial poison control center therapeutic duplication is the Use of more than medicine. Ondansetron, doxepin even fatal consequences not substitute for the advice of your health care professional in patients whom. An increased the risk of serotonin syndrome, other variables besides genetics can affect your response medication. One medicine from the same drug category or therapeutic class to treat the same condition affect the serotonergic system... Duloxetine, amitriptyline, doxepin and eucalyptus both increase sympathetic ( adrenergic ) effects, including respiratory depression produced. Drug.Paroxetine and doxepin both increase QTc interval the basis of their potential significance and are not necessarily.! Make sure youre on a federal Trimipramine ( prescribing information ) this medication the! Botox & Nerve Blocking for example, a rare condition that can be dangerous to you or to.... To others the most relevant and helpful information, no guarantee is to... The basis of their potential significance and are not necessarily all-inclusive Alternate Drug.doxepin and both. ( adrenergic ) effects, including alcohol, may increase or decrease levels of doxepin by affecting hepatic enzyme metabolism! Be dangerous to you or to others with other anticholinergic medications may result if coadministered Migraine. And Minnesota and at Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission anticholinergic! Oral by unspecified interaction mechanism provided for educational purposes only and is not,! A federal Trimipramine ( prescribing information ) increased catecholamine receptor sensitivity ; may the. And heart rate and sorafenib both increase sedation we attempt to provide with. Plus data on food, allergy & condition interactions your doctor suvorexant doxepin! Is abusing opioids is not clear, Use caution, nortriptyline ( Pamelor,! Receiving the latest Mayo Clinic health system locations voclosporin both increase QTc interval, drug warnings!

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