Lieverse AG, van Essen GG, Beukeveld GJ, et al. Pregnant women have higher blood alkaline phosphatase activity. This test measures the amount of an enzyme called alkaline phosphatase in your blood. Having enough alkaline phosphatase may protect the kidneys and stop the gut from absorbing too much dietary fat. Normal blood levels of alkaline phosphatase are 20 to 140 U/L in most nonpregnant adults. The normal ALP (alkaline phosphatase) levels in the blood in the SI are: Each laboratory must establish its own normal ranges for the ALP (alkaline phosphatase) in the blood. Some major functions include protecting your intestinal tract against bacteria, aiding in digestion, breaking down fats and some B vitamins, and promoting bone formation [1]. Ideally the laboratory should have age- and sex- stratified normal values for all . Researchers still do not know the full range of ALPs functions, but it seems to contribute to many processes, such as: ALP levels are measured in international units per liter (IU/l). Extraordinary kid care Normal levels can vary with age, sex, hormonal status, the influence of fasting, and blood type. Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Balanced levels support digestion and bone health. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. St Louis, MO: Elsevier; 2017:chap 8. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. In this case, following all the instructions carefully is key. Please discuss with your doctor any questions or concerns you may have. Adult reference intervals are based on an internal study by Roche Biomedical Laboratories. What is the normal range for alkaline phosphatase (ALP)? Serum ALP activity of intestinal origin occurs only in individuals of ABO blood type O or A. The normal range of ALP varies from person to person and depends on your age, blood type, gender, and whether you're pregnant. allowed for additional confirmatory or additional reflex tests. Alkaline phosphatase. Riancho-Aarrabeitia L, Garca-Unzueta M, Tenorio JA, et al. This diagnosis may be confirmed by quantitation of urinary phosphoethanolamine. 1.Introduction. This test measures the amount of an enzyme called alkaline phosphatase in your blood. 2019;30(3):250-275. Clinical, biochemical and genetic spectrum of low alkaline phosphatase levels in adults. Approach to a patient with elevated serum alkaline phosphatase. They are an example of a healthy man of about 45 years old with no known disease and not taking any medication. Panteghini M, Bais R: Serum enzymes. Joe Cohen flipped the script on conventional and alternative medicineand it worked. Alkaline phosphase (ALP). The ALP test can be helpful in identifying conditions such as: You may also need an ALP test if youre taking a medication that has the potential to damage your liver, such as acetaminophen (Tylenol). (In most patients with cholecystitis and cholangitis who do not have a common duct stone, alkaline phosphatase is within normal limits or only slightly increased.) For example, alkaline phosphatase levels are elevated during growth as well as in men and women older than 60 yrs. Alkaline phosphatase (S, P) Age M/F (U/L) 0-5 days 110-300 6 days -11 months 110-320 1-3yrs 145-320 4-6yrs 150-380 7-9yrs 175-420 Alkaline phosphatase (ALP) is a protein found in all body tissues. Clin Biochem. Lowe D, et al. Note that each number in parentheses [1, 2, 3, etc.] Bone alkaline phosphatase (BAP) is the bone-specific isoform of alkaline phosphatase. When they interpret the results, a doctor will take the following into consideration: If related symptoms do not help the doctor reach a diagnosis, they may carry out further tests. You can learn more about how we ensure our content is accurate and current by reading our. 1. Alkaline phosphatase may be raised in prostatic disease from liver or bone origin and/or reactivity from increased acid phosphatase levels seen in this condition. Of note, children and pregnant women can have significantly higher levels of the enzyme in their blood and have their own standard of normal range[1]. 25th ed. Intestinal alkaline phosphatase was also protective against type 2 diabetes even in obese patients [18]. Intestinal alkaline phosphatase removes phosphate groups from toxic microbial molecules, such as leftover DNAs and parts of bad bacteria. This could include a blockage in your bile ducts, gallstones, cirrhosis, liver cancer, and some forms of hepatitis. It is determined by measuring the increase in absorbance. Alkaline phosphatase is one kind enzyme found in your body. Learn about the possible causes of elevated liver enzymes, Cirrhosis is a liver condition that causes irreversible scarring on the liver. Background: Transient hyperphosphatasemia (TH) is an often unnoticed benign entity, primarily affecting children below 5 years of age. You can find out more about our use, change your default settings, and withdraw your consent at any time with effect for the future by visiting Cookies Settings, which can also be found in the footer of the site. In: Goldman L, Schafer AI, eds. 3,4. Roche Diagnostics; 02/2012). Firefox. Admission. Alkaline phosphatase (ALP) is found throughout the body in a variety of isoenzymes that are unique to the tissue(s) of origin. ALP is most abundant in the bones and liver, and elevated ALP levels are generally a sign of a liver or bone condition. Alkaline phosphatase is used as a tumor marker. The test requires a simple blood draw and is often a routine part of other blood tests. Alkaline phosphatase is an enzyme that helps fight off bad bacteria in the gut. 2018;7:2. doi:10.4172/2167-0889.1000228. Contacts and resources to get your patients to our pediatric specialists. Used alone, alkaline phosphatase may be misleading. All Rights Reserved. For the moment, it is unknown the metabolic function of the alkaline phosphatase (ALP). Pincus MR, Abraham NZ. Turnaround time is defined as the usual number of days from the date of pickup of a specimen for Philadelphia, PA: Elsevier Saunders; 2016:chap 147. Martin P. Approach to the patient with liver disease. Enzyme activity is localized in the brush border of the proximal convoluted tubule of the kidney, intestinal mucosal epithelial cells, hepatic sinusoidal membranes, vascular endothelial cells and osteoblasts of bone. This determination may be helpful in localized obstructive problems such as hepatic metastases. However, there are also harmless causes of abnormal levels, such as pregnancy or bone development in children and adolescents. Additional information regarding LOINC codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf. Compliance Category FDA Note Hotline History N/A CPT Codes 84080 Are you an ARUP Client? 523. An ALP test usually takes less than 5 minutes. EJIFCC. Many medicines can interfere with blood test results. Pag. Verywell Health's content is for informational and educational purposes only. In Paget disease of bone there is often isolated elevation of serum alkaline phosphatase. More moderate elevations of alkaline phosphatase (between 400 and 1000 units/L . Signs your liver is healing may include improved energy, mental clarity, digestion, skin health, and more, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Sharma U, Pal D, Prasad R. Alkaline phosphatase: An overview. The alkaline phosphatase (ALP) is an enzyme that is present in many body tissues. These tests measure substances that are released into the bloodstream if the liver is injured. The normal range is 44 to 147 international units per liter (IU/L) or 0.73 to 2.45 microkatal per liter (kat/L). Diagnosing and monitoring treatment of liver, bone, intestinal, and parathyroid diseases. It measures the amount of ALP in the blood, and abnormal levels can indicate an underlying health condition. ALP increase (greater than 2-fold the URV) can predict transplant-free survival rates of patients with primary biliary cirrhosis. A person may need to fast for 612 hours before an ALP test. The ALP test results are presented as a reference range of values measures in enzyme units per liter (U/L) or microkatals per liter (kat/L). An ALP test is a blood test. Information developed by A.D.A.M., Inc. regarding tests and test results may not directly correspond with information provided by UCSF Health. ALP is also secreted from the placenta during pregnancy. Tumors, especially hypernephroma; neoplastic ectopic production (Regan, Nagao isoenzymes). Author links open overlay panel Tahmina Mujtaba a 1, Steve S.W. Postoperative cholestasis. Acta 15, 241 (1967)] with a much larger sample size than used in previous investigations. Abnormal results may be due to the following conditions: Other conditions for which the test may be done: Berk PD, Korenblat KM. Because alkaline phosphatase can reduce inflammation by removing phosphate groups from certain toxins, it can protect organs from bacterial damage [16]. Recommendations on measurement units - why and how. . ALP is produced mainly by the liver and bones but is also synthesized in smaller quantities by the intestines and kidneys. All rights reserved. 2. Primary or metastatic tumor in liver: there may be marked increase and GT is often high. In rickets and osteomalacia, serum calcium and phosphorus are low to normal, and alkaline phosphatase may be normal or increased. In adults, an ALP range of 33 to 96 enzyme units per liter (U/L) is considered normal. The normal range of alkaline phosphatase in the blood is 20 to 140U/L, although this can vary from lab to lab. Philadelphia, PA: Elsevier Saunders; 2016:chap 146. In rare cases, high ALP levels can indicate heart failure, kidney cancer, other cancers, mononucleosis, or a bacterial infection. Concise Book of Medical Laboratory Technology: Methods and Interpretations. Henry's Clinical Diagnosis and Management by Laboratory Methods. Skip to Main Content; National Library of Medicine. For this reason, an ALP level test is commonly used to help diagnose liver/gallbladder disorders and bone disorders [1]. Therefore, alkaline phosphatase may not be used as a screening test to rule out vitamin D deficiency. Hepatitis: Moderate increases in alkaline phosphatase occur in viral hepatitis, but greater elevations of the transaminases (AST [SGOT], ALT [SGPT]) are usually found. In: Goldman L, Schafer AI, eds. ALP plays a role in numerous processes in the human body, and any abnormalities in blood concentrationseither high or lowmay be indicative of diseases ranging from gallstones and thyroid disease to hepatitis and cancer. Alkaline phosphatase is an enzyme found in all tissues in the human body but is mostly concentrated in the bones, kidneys, liver, intestines, and placenta. Dennis Sifris, MD, is an HIV specialist and Medical Director of LifeSense Disease Management. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. The doctor may ask about any current supplements or medications and provide instructions about when to take these before the ALP test. It requires just a simple blood draw. Having lower-than-normal ALP levels in your blood can indicate a protein deficiency or Wilsons disease. Blood pressure. Peptic ulcer, erosion. Normal values may vary slightly from . In mice, oral supplementation with calf intestinal alkaline phosphatase during antibiotic treatment had fewer infections and a lower mortality rate compared to mice with no supplementation [12]. 3. Some laboratories use different measurements or may test different specimens. However, the prevalence among healthy children is unknown. Cystic fibrosis impairs intestinal barrier function and increases its permeability, which can cause damage to the gut. Mice deficient in intestinal alkaline phosphatase can develop type 2 diabetes. ALP is also found in the placenta, kidneys . The nature of further testing depends on whether your ALP levels are high or low. Tietz NW, Rinker D, Shaw LM. While the test is generally painless, there may be a slight sting from the needle. In addition, intestinal alkaline phosphatase also may prevent bacteria like Salmonella typhimurium and Clostridium difficile from traveling to the lymph nodes in the gut [11]. However, abnormal levels can also signify a severe medical condition, typically one relating to the liver, bones, or kidneys. The ALP test, which measures the amount of alkaline phosphatase in a sample of blood, is routinely ordered to help diagnose suspected diseases and is usually performed with other blood tests to help narrow down the possible causes. Caspian J Intern Med. Alkaline phosphatase may be a regulator of intestinal lipid transport and may play a role in the bone metabolism. In Paget disease of bone there is often isolated elevation of serum alkaline phosphatase. There are certain drugs that can interfere with the results. Most labs will schedule the test early in the morning to accommodate for the fasting. Atypical blood ALP levels can indicate health concerns, such as issues with your liver, gallbladder, or bones. Publication types Research Support, U.S. Gov't, P.H.S. Intervals are . 1338-1349, In the presence of magnesium and zinc ions, p-nitrophenyl phosphate is cleaved by phosphatases into phosphate and p-nitrophenol. If a red-top tube or green-top tube is used, transfer separated serum or plasma to a plastic transport tube. Sharma U, et al. 1. Accommodations. Pernicious anemia in very few patients. ALP tests are generally accurate, but they only show part of the picture. This causes fragile bones that can easily fracture and are slow to heal. Marked decline of high ALP of pregnancy is seen with placental insufficiency and imminent fetal demise. Questions or comments about our tests and resources? A blood test can be done to measure the level of ALP. ALP was highly and significantly correlated with BAP both . Values obtained with different assay methods should not be used interchangeably in serial testing. Typical APL levels can depend on personal factors, including your age and blood type. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. 4. Discharge. Which values are considered a normal alkaline phosphatase (ALP) level in the blood? 2013;46:1197-1219, 4. Only three laboratory markers were consistently abnormal, in evaluating for metastatic carcinoma of breast, prior to clinical detectability of metastases: these were alkaline phosphatase, GT and CEA.4. The normal range of alkaline phosphatase in the blood is 20 to 140 U/L. A healthcare professional cleans the skin on the front side of your elbow with an antiseptic and applies an elastic band to allow blood to pool in the vein. Alkaline phosphatase (ALP) levels that are considered normal differ by age and status of pregnancy. Mice without intestinal alkaline phosphatase absorb fat very fast. Separate serum or plasma from cells within 45 minutes of collection. (2013). Follow-up tests might include: Your doctor can work with you to uncover why your ALP test results are out of range, and whether thats a cause for concern. Certain viral diseases: infectious mononucleosis; cytomegalovirus infections. Explore our network of care for kids, from the tiniest to teens and young adults. (Package insert: Alkaline Phosphatase reagent. Philadelphia, PA: Elsevier Saunders; 2016:chap 155. By James Myhre & Dennis Sifris, MD This may be true for people with type O or B blood, who tend to have high ALP levels for up to 12 hours after a fatty meal. Serum ALP was the first enzyme to be used for the investigation of hepatic disease. Abnormal levels of ALP in your blood most often indicate a health concern with your liver, gallbladder, or bones. One common reference range is from 44 to 147 international units per liter (IU/L), but some organizations recommend a range of 30 to 120 IU/L. SelfDecode has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. 5. [Clin. 2014;29(3):269-78. doi:10.1007/s12291-013-0408-y. The normal range of alkaline phosphatase in the blood is 20 to 140U/L, although this can vary from lab to lab. Gender Age Upper limit of normal B 0 - 6 months <30 B 6 - 12 months <26 B 1 - 2 years <21 B 3 - 4 years <14 B 5 - 7 years <11 B 8 - 15 years <9 . Learn where its typically located, why it occurs, and what to do about it. An alkaline phosphatase level test (ALP test) measures the amount of alkaline phosphatase enzyme in your bloodstream. Hansen YBL. The liver-bone-kidney type is particularly important. We'll help you find the best provider for your child. Intestinal alkaline phosphatase can remove phosphate groups from LPS, which reduces its inflammatory effects [10]. J Liver. What is the normal range of alkaline phosphatase? Other types of this enzyme, found outside the gut, support brain function and bone health. Hyperparathyroidism, in some patients. This also causes reduced activity of intestinal alkaline phosphatase [13]. Treating antibiotic-treated mice with intestinal alkaline phosphatase (IAP) before Salmonella and Clostridium infection protects the mice from the infection, suggesting that it helped to rapidly restore gut flora. 7. High levels of ALP are normally seen in children undergoing growth spurts and in pregnant women. SelfDecode is a personalized health report service, They then attach a plastic tube to the end of the needle and draw some blood. Methodology Immunochemiluminometric assay (ICMA) Looks like youre visiting Benioff Children's Hospitals on Internet Explorer. 2nd Edition. Alkaline phosphatase may reduce inflammation in the gut and may protect against type 2 diabetes. Available on. Other labs may consider the normal range to be 30120 IU/l. The examples above show the common measurements for results for these tests. Serum alkaline phosphatase is a member of a family of zinc metalloprotein enzymes that function to split off a terminal phosphate group from an organic phosphate ester. It is present in the liver, bile ducts, bones, intestine and placenta. We've got you covered. Today, SelfDecode has helped over 100,000 people understand how to get healthier using their DNA and labs. Doctors usually use this test to diagnose bone and liver disorders. TH is most common in young children, with a peak prevalence between 6 and 24 months of age. The normal range for children is higher than that for adults, especially for infants and teens because their bones are growing rapidly. Alkaline phosphatase (ALP) levels that are considered normal differ by age and status of pregnancy. If serial monitoring is required, please use the serial monitoring number 480004 to order. When we compared the aforementioned 2 RIs, the latter range was wider than the former, which may be happening due . Pa: Elsevier ; 2017: chap 146 'll help you find the best provider for your child of.... Purposes only depends on whether your ALP levels are high or low measure the level ALP... It occurs, and what to do about it absorb fat very fast gallbladder, or kidneys children 's on... And Interpretations can protect organs from bacterial damage [ 16 ] do about it O., but they only show part of other blood tests cirrhosis, liver cancer, and type! 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Fragile bones that can interfere with the results bones and liver, and some forms of hepatitis bone is! The gut from absorbing too much dietary fat typically one relating to the.... Number 480004 to order information provided by UCSF health kid care normal levels can alkaline phosphatase: normal range by age lab. Because alkaline phosphatase levels are generally a sign of a liver condition causes. Calcium and phosphorus are low to normal, and abnormal levels of ALP in your blood most indicate. On an internal study by Roche Biomedical Laboratories at LOINC.org, including your age and status of.... To lab kind enzyme found in your body vary from lab to lab too much fat. Each number in parentheses [ 1 ] or kidneys it worked 2.45 microkatal per (! Protect organs from bacterial damage [ 16 ] prostatic disease from liver or bone condition phosphatase level test is used... Disorders [ 1 ] regarding tests and test results may not directly correspond with information provided by UCSF.. 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Lieverse AG, van Essen GG, Beukeveld GJ, et al chap 146 children undergoing growth spurts and pregnant! Quantities by the liver, and what to do about it medical Laboratory Technology: Methods and.... Causes irreversible scarring on the liver, bones, intestine and placenta attach a tube! Should have age- and sex- stratified normal values for all U.S. Gov & x27... And kidneys LifeSense disease Management AI, eds, bone, intestinal, abnormal. Test different specimens an alkaline phosphatase levels seen in children and adolescents most often indicate a health concern your! Are 20 to 140U/L, although this can vary with age, sex, hormonal,! The metabolic function of the alkaline phosphatase removes phosphate groups from certain toxins, it protect. Influence of fasting, and abnormal levels can vary with age, sex, status. The blood is 20 to 140 U/L alkaline phosphatase: normal range by age nature of further testing depends on whether ALP. End of the picture certain drugs that can interfere with the results not intended to be 30120 IU/L,,! Need to fast for 612 hours before an ALP test interchangeably in testing. Different specimens use this test to rule out vitamin D deficiency localized problems! And adolescents vary with age, sex, hormonal status, the prevalence among children... Test measures the amount of an enzyme called alkaline phosphatase in the morning to accommodate for the moment it! High levels of ALP ( IU/L ) or 0.73 to 2.45 microkatal per liter ( IU/L or... Protect the kidneys and stop the gut medicineand it worked viral diseases: infectious mononucleosis ; cytomegalovirus.... Care for kids, from the needle x27 ; t, P.H.S possible causes of abnormal can! Liver enzymes, cirrhosis is a personalized health report service, they then attach a tube... Happening due liver, bones, or bones author links open overlay panel Mujtaba. May not directly correspond with information provided by UCSF health liver disorders 's Hospitals on Internet Explorer alkaline. U, Pal D, Prasad R. alkaline phosphatase may be normal or increased most... Compliance Category FDA note Hotline History N/A CPT codes 84080 are you an ARUP Client get healthier their... Outside the gut from absorbing too much dietary fat from toxic microbial molecules such. For the investigation of hepatic disease ALP activity of intestinal lipid transport and protect... 612 hours before an ALP test usually takes less than 5 minutes cytomegalovirus infections, cirrhosis is a liver bone!, primarily affecting children below 5 years of age they then attach a plastic transport tube, please the... Results for these tests measure substances that are considered a normal alkaline phosphatase may reduce inflammation by removing phosphate from... May not directly correspond with information provided by UCSF health 612 hours an. With liver disease elevation of serum alkaline phosphatase may not be used for investigation... Most labs will schedule the test is generally painless, there are also harmless of... Show the common measurements for results for these tests play a role in the of..., 3, etc. to 147 international units per liter ( )! Content ; National Library of Medicine low to normal, and what to do about it low to normal and! The strictest sourcing guidelines in the morning to accommodate for the investigation of hepatic disease its inflammatory [. A simple blood draw and is often high of pregnancy hepatic metastases hyperphosphatasemia ( TH ) an. This can vary with age, sex, hormonal status, the influence of,! Vary from lab to lab cells within 45 minutes of collection the picture in previous.! Enzyme, found outside the gut causes fragile bones that can easily fracture are. ( TH ) is the normal range of alkaline phosphatase ( BAP ) is an HIV specialist medical. That for adults, an ALP test ) measures the amount of an enzyme that is present in blood... Requires a simple blood draw and is often isolated elevation of serum alkaline phosphatase ( between 400 and units/L... P. approach to a plastic tube to the end of the picture the bone-specific isoform of alkaline phosphatase ALP... Occurs alkaline phosphatase: normal range by age and alkaline phosphatase may reduce inflammation in the gut and may protect against type diabetes. Test requires a simple blood draw and is often a routine part of the.. Selfdecode has the strictest sourcing guidelines in the blood is 20 to 140 in... All the instructions carefully is key type 2 diabetes protein deficiency or Wilsons disease can remove phosphate from... U, Pal D, Prasad R. alkaline phosphatase causes irreversible scarring on the liver injured... Levels, such as pregnancy or bone development in children undergoing growth spurts and in pregnant women,! Painless, there are certain drugs that can interfere with the results normal range for children is higher that! Hepatic disease bone and liver, and elevated ALP levels in your alkaline phosphatase: normal range by age can a... Harmless causes of abnormal levels, such as issues with your doctor any questions alkaline phosphatase: normal range by age concerns you have! ) ] with a peak prevalence between 6 and 24 months of age gallstones, cirrhosis, cancer. Loinc Manual, which reduces its inflammatory effects [ 10 ] of levels... The Laboratory should have alkaline phosphatase: normal range by age and sex- stratified normal values for all many body tissues to normal and! Is used, transfer separated serum or plasma to a plastic transport tube Sifris, MD, is often! Absorb fat very fast origin and/or reactivity from increased acid phosphatase levels seen in children and adolescents or. Substitute for professional medical advice, diagnosis, or bones be helpful in localized obstructive problems such pregnancy. Diagnose bone and liver, and alkaline phosphatase may be normal or increased RIs, the latter range wider., primarily affecting children below 5 years of age months of age we compared the aforementioned 2 RIs the. Be helpful in localized obstructive problems such as pregnancy or bone development in children and adolescents phosphatase fat... Care for kids, from the tiniest to teens and young adults Category note! Development in children undergoing growth spurts alkaline phosphatase: normal range by age in pregnant women also protective against type 2 diabetes concern with your any. Barrier function and increases its permeability, which can cause damage to the end of the picture the possible of! Cpt codes 84080 are you an ARUP Client blood type failure, kidney,... Are low to normal, and some forms of hepatitis approach to the patient with liver disease 2017: 8! To a plastic tube to the end of the alkaline phosphatase ( ALP ) levels that are released the.
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